Qwen2.5 72B Instruct vs Mistral Large 2 (2407): local, rented GPU, and API costs

Compare calculated local requirements, provider-published rented-GPU rates, and dated API rates or clearly labeled size estimates for Qwen2.5 72B Instruct and Mistral Large 2 (2407). Spanvero adds $0 markup.

Qwen2.5 72B Instruct vs Mistral Large 2 (2407) — cost comparison

Which should you pick?

• Easiest to run locally: Qwen2.5 72B Instruct (needs ~54 GB VRAM at its default quant).
• Pay-as-you-go (your own API key): Qwen2.5 72B Instruct ~$0.68/1M vs Mistral Large 2 (2407) ~$1.08/1M — size-based estimates; check each provider's current listing or verify against Spanvero's dated pricing table.
• Cheapest to rent by the hour: Qwen2.5 72B Instruct (from $0.30/hr on one rented box).
• Longest context: Either — same context window.

VRAM is calculated from catalog specs, quantization, and context. Non-estimated API rates are provider-sourced snapshots dated 2026-08-24; retired upstream rates are last-known and size-derived values are labeled "est." We don't rank model quality or quote benchmarks here.

Full cost breakdown: Qwen2.5 72B Instruct →
Full cost breakdown: Mistral Large 2 (2407) →

Open the free LLM cost calculator → to model your workload, hardware, monthly cost, and reliability assumptions.

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Spanvero · All comparisons · Prices as of 2026-08-24. $0 markup, your own accounts, we never resell compute. © 2026 Cynosure LLC.