Can NVIDIA RTX 5080 16GB run Llama, Qwen & DeepSeek? 264 models that fit

264 of the 396 models in the Spanvero catalog fit NVIDIA RTX 5080 16GB's 16 GB VRAM (at a sensible quant, 16k context). For each: run it locally ($0 compute + electricity), rent an equivalent GPU ($0 markup, as of 2026-07-02), or pay per-token via your own API key (as of 2026-07-06).

Three honest ways to run each model on NVIDIA RTX 5080 16GB

• Run it locally: $0 in compute — you pay only electricity (~360 W under load on this card). Local is real money, never a fake "$0".
• Rent an equivalent GPU: from a $0-markup vendor rate (as of 2026-07-02) — you rent on your own account and pay the vendor directly; we never resell compute.
• Skip the box: run the same model through your own API key, paying per million tokens (prices as of 2026-07-06).

What fits NVIDIA RTX 5080 16GB (16 GB VRAM)

• 264 of the 396 notable models in the Spanvero catalog fit NVIDIA RTX 5080 16GB at a sensible quant (context capped at 16k for the estimate). Most capable first:
• gpt oss safeguard 20b (openai, 21.5B) — needs ~16 GB at Q4_K_M: run it locally for $0 compute + ~$0.3775/1M in electricity, rent 2× NVIDIA RTX 3060 12GB from $0.12/hr ($0 markup), or ~$0.19/1M via your own API key.
• gpt-oss-20b (OpenAI, 21B) — needs ~15 GB at Q4_K_M: run it locally for $0 compute + ~$0.3705/1M in electricity, rent 2× NVIDIA RTX 3060 12GB from $0.12/hr ($0 markup), or ~$0.08/1M via your own API key.
• gpt oss 20b BF16 (unsloth, 20.9B) — needs ~15 GB at Q4_K_M: run it locally for $0 compute + ~$0.3691/1M in electricity, rent 2× NVIDIA RTX 3060 12GB from $0.12/hr ($0 markup), or ~$0.27/1M via your own API key (size estimate).
• NVIDIA Nemotron 3 Nano 30B A3B NVFP4 (nvidia, 18.2B) — needs ~13 GB at Q4_K_M: run it locally for $0 compute + ~$0.3304/1M in electricity, rent 2× NVIDIA RTX 3060 12GB from $0.12/hr ($0 markup), or ~$0.25/1M via your own API key (size estimate).
• Qwen3 30B A3B NVFP4 (RedHatAI, 17.5B) — needs ~13 GB at Q4_K_M: run it locally for $0 compute + ~$0.3202/1M in electricity, rent 2× NVIDIA RTX 3060 12GB from $0.12/hr ($0 markup), or ~$0.24/1M via your own API key (size estimate).
• Qwen3 32B NVFP4 (nvidia, 17.2B) — needs ~15 GB at Q4_K_M: run it locally for $0 compute + ~$0.3158/1M in electricity, rent 2× NVIDIA RTX 3060 12GB from $0.12/hr ($0 markup), or ~$0.24/1M via your own API key (size estimate).
• deepseek moe 16b base (deepseek-ai, 16.4B) — needs ~12 GB at Q4_K_M: run it locally for $0 compute + ~$0.304/1M in electricity, rent 2× NVIDIA RTX 3060 12GB from $0.12/hr ($0 markup), or ~$0.23/1M via your own API key (size estimate).
• deepseek moe 16b chat (deepseek-ai, 16.4B) — needs ~12 GB at Q4_K_M: run it locally for $0 compute + ~$0.304/1M in electricity, rent 2× NVIDIA RTX 3060 12GB from $0.12/hr ($0 markup), or ~$0.23/1M via your own API key (size estimate).
• LLaDA2.0 mini (inclusionAI, 16.3B) — needs ~12 GB at Q4_K_M: run it locally for $0 compute + ~$0.3025/1M in electricity, rent 2× NVIDIA RTX 3060 12GB from $0.12/hr ($0 markup), or ~$0.23/1M via your own API key (size estimate).
• DeepSeek-Coder-V2-Lite Instruct (DeepSeek, 15.7B) — needs ~11 GB at Q4_K_M: run it locally for $0 compute + ~$0.2936/1M in electricity, rent 2× NVIDIA RTX 3060 12GB from $0.12/hr ($0 markup), or ~$0.23/1M via your own API key (size estimate).
• DeepSeek V2 Lite Chat (deepseek-ai, 15.7B) — needs ~15 GB at Q4_K_M: run it locally for $0 compute + ~$0.2936/1M in electricity, rent 2× NVIDIA RTX 3060 12GB from $0.12/hr ($0 markup), or ~$0.23/1M via your own API key (size estimate).
• DeepSeek V2 Lite (deepseek-ai, 15.7B) — needs ~15 GB at Q4_K_M: run it locally for $0 compute + ~$0.2936/1M in electricity, rent 2× NVIDIA RTX 3060 12GB from $0.12/hr ($0 markup), or ~$0.23/1M via your own API key (size estimate).
• Qwen3 30B A3B NVFP4 (nvidia, 15.6B) — needs ~12 GB at Q4_K_M: run it locally for $0 compute + ~$0.2921/1M in electricity, rent 2× NVIDIA RTX 3060 12GB from $0.12/hr ($0 markup), or ~$0.22/1M via your own API key (size estimate).
• Qwen2.5 Coder 14B Instruct (Qwen, 14.8B) — needs ~14 GB at Q4_K_M: run it locally for $0 compute + ~$0.28/1M in electricity, rent 2× NVIDIA RTX 3060 12GB from $0.12/hr ($0 markup), or ~$0.22/1M via your own API key (size estimate).
• Qwen2.5 14B Instruct (Qwen, 14.8B) — needs ~14 GB at Q4_K_M: run it locally for $0 compute + ~$0.28/1M in electricity, rent 2× NVIDIA RTX 3060 12GB from $0.12/hr ($0 markup), or ~$0.22/1M via your own API key (size estimate).
• Qwen3 14B (Qwen, 14.8B) — needs ~13 GB at Q4_K_M: run it locally for $0 compute + ~$0.28/1M in electricity, rent 2× NVIDIA RTX 3060 12GB from $0.12/hr ($0 markup), or ~$0.17/1M via your own API key.
• Qwen2.5 14B Instruct (unsloth, 14.8B) — needs ~14 GB at Q4_K_M: run it locally for $0 compute + ~$0.28/1M in electricity, rent 2× NVIDIA RTX 3060 12GB from $0.12/hr ($0 markup), or ~$0.22/1M via your own API key (size estimate).
• phi 4 quantized.w4a16 (RedHatAI, 14.8B) — needs ~14 GB at Q4_K_M: run it locally for $0 compute + ~$0.28/1M in electricity, rent 2× NVIDIA RTX 3060 12GB from $0.12/hr ($0 markup), or ~$0.22/1M via your own API key (size estimate).
• Qwen3 14B Base (Qwen, 14.8B) — needs ~13 GB at Q4_K_M: run it locally for $0 compute + ~$0.28/1M in electricity, rent 2× NVIDIA RTX 3060 12GB from $0.12/hr ($0 markup), or ~$0.22/1M via your own API key (size estimate).
• HyperCLOVAX SEED Think 14B (naver-hyperclovax, 14.7B) — needs ~13 GB at Q4_K_M: run it locally for $0 compute + ~$0.2785/1M in electricity, rent 2× NVIDIA RTX 3060 12GB from $0.12/hr ($0 markup), or ~$0.22/1M via your own API key (size estimate).

• gpt oss safeguard 20b — full cost breakdown
• gpt-oss-20b — full cost breakdown
• gpt oss 20b BF16 — full cost breakdown
• NVIDIA Nemotron 3 Nano 30B A3B NVFP4 — full cost breakdown
• Qwen3 30B A3B NVFP4 — full cost breakdown
• Qwen3 32B NVFP4 — full cost breakdown
• deepseek moe 16b base — full cost breakdown
• deepseek moe 16b chat — full cost breakdown
• LLaDA2.0 mini — full cost breakdown
• DeepSeek-Coder-V2-Lite Instruct — full cost breakdown
• DeepSeek V2 Lite Chat — full cost breakdown
• DeepSeek V2 Lite — full cost breakdown
• Qwen3 30B A3B NVFP4 — full cost breakdown
• Qwen2.5 Coder 14B Instruct — full cost breakdown
• Qwen2.5 14B Instruct — full cost breakdown
• Qwen3 14B — full cost breakdown
• Qwen2.5 14B Instruct — full cost breakdown
• phi 4 quantized.w4a16 — full cost breakdown
• Qwen3 14B Base — full cost breakdown
• HyperCLOVAX SEED Think 14B — full cost breakdown

The honest cost of owning NVIDIA RTX 5080 16GB

• The full ownership math for this card — its dated street price, 3-year amortization, electricity, and the own-vs-rent break-evens — lives on the dedicated NVIDIA RTX 5080 16GB GPU page (linked under "Keep exploring" below), so those numbers are published once, in one place.

Too big for NVIDIA RTX 5080 16GB — rent or use an API instead

• These need more than the 16 GB VRAM on this card. Closest first — you can still run them on a rented GPU ($0 markup) or via your own API key:
• gpt neox 20b (EleutherAI, 20.7B) — needs ~17 GB; rent 2× NVIDIA RTX 3060 12GB from $0.12/hr, or ~$0.27/1M via your own API key (size estimate).
• Gemma 4 26B A4B NVFP4 (nvidia, 14.4B) — needs ~17 GB; rent 2× NVIDIA RTX 3060 12GB from $0.12/hr, or ~$0.22/1M via your own API key (size estimate).
• diffusiongemma 26B A4B it NVFP4 (nvidia, 14.4B) — needs ~17 GB; rent 2× NVIDIA RTX 3060 12GB from $0.12/hr, or ~$0.22/1M via your own API key (size estimate).
• LFM2 24B A2B (LiquidAI, 23.8B) — needs ~18 GB; rent 2× NVIDIA RTX 3060 12GB from $0.12/hr, or ~$0.29/1M via your own API key (size estimate).
• Gemma 4 26B A4B it NVFP4 (bg-digitalservices, 15.1B) — needs ~18 GB; rent 2× NVIDIA RTX 3060 12GB from $0.12/hr, or ~$0.22/1M via your own API key (size estimate).
• Trinity Mini (arcee-ai, 26.1B) — needs ~19 GB; rent 2× NVIDIA RTX 3060 12GB from $0.12/hr, or ~$0.10/1M via your own API key.

Keep exploring

• NVIDIA RTX 5080 16GB — rent rates, own-vs-rent math & what fits
• Check a different GPU or Mac
• All GPUs — rental rates compared
• Free cost calculator — local vs rent vs API
• All models — the real cost to run each
• How we stay honest

Open the free Spanvero advisor → · GPU rates as of 2026-07-02, API prices as of 2026-07-06. Honest, $0-markup — your own accounts, we never resell compute. © 2026 Cynosure LLC.