DeepSeek-V3 vs Qwen2.5 72B Instruct: the real cost to run each

The honest, $0-markup cost to run DeepSeek-V3 (DeepSeek, 671B) and Qwen2.5 72B Instruct (Alibaba, 72B), side by side — free on your own machine, on your own rented GPU at the vendor's price, or via your own API key.

DeepSeek-V3 vs Qwen2.5 72B Instruct — cost comparison

Which should you pick?

• Easiest to run locally: Qwen2.5 72B Instruct (needs ~54 GB VRAM at its default quant).
• Pay-as-you-go (your own API key): DeepSeek-V3 ~$0.50/1M vs Qwen2.5 72B Instruct ~$0.68/1M — size-based estimates; open the advisor for live prices.
• Cheapest to rent by the hour: Qwen2.5 72B Instruct (from $0.30/hr on one rented box).
• Longest context: Either — same context window.

VRAM, size, context and license are facts from the catalog and the shared cost engine; API prices are real where we have them (labeled "est." otherwise). We don't rank model quality or quote benchmarks here.

Full cost breakdown: DeepSeek-V3 →
Full cost breakdown: Qwen2.5 72B Instruct →

Open the free Spanvero advisor → to compare them live for your exact workload and hardware.

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Spanvero · All comparisons · Prices as of 2026-07-06. $0 markup, your own accounts, we never resell compute. © 2026 Cynosure LLC.